Long-term glucocorticoid therapy, such as prednisone, is associated with osteoporosis. Which condition is most associated with this risk?

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Multiple Choice

Long-term glucocorticoid therapy, such as prednisone, is associated with osteoporosis. Which condition is most associated with this risk?

Long-term glucocorticoid therapy disrupts bone remodeling, making bones fragile and prone to fracture. These drugs suppress osteoblast activity and lifespan while promoting osteoclast survival, tilt calcium balance toward loss by reducing gut absorption and increasing urinary excretion, and can diminish protective sex-hormone effects on bone. The net result is secondary osteoporosis, so osteoporosis is the condition most associated with chronic steroid use. (Steroids can cause other metabolic effects like hyperglycemia or hypertension, but the direct bone complication is osteoporosis.)

Long-term glucocorticoid therapy, such as prednisone, is associated with osteoporosis. Which condition is most associated with this risk?

Prepare for the Chronic Illness Test. Study with interactive questions and detailed explanations. Be confident in your knowledge!

Long-term glucocorticoid therapy, such as prednisone, is associated with osteoporosis. Which condition is most associated with this risk?

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