Long-term prednisone therapy for rheumatoid arthritis requires supplementation to prevent osteoporosis. Which supplement should be taken?

• A. Iron and Vitamin B12
• B. Calcium & Vitamin D
• C. Potassium & Magnesium
• D. Vitamin C & E

Answer: (B)

Chronic prednisone use can cause osteoporosis by slowing bone formation and increasing bone breakdown, while also reducing how well the body absorbs calcium and increasing calcium loss. Calcium provides the essential mineral for bone structure, and vitamin D is needed for proper calcium absorption and bone mineralization. Together, calcium and vitamin D help maintain bone density and reduce fracture risk during long-term glucocorticoid therapy. The other options don’t directly address bone health: iron and B12 target anemia, potassium and magnesium are not primary preventive measures for glucocorticoid-induced bone loss, and vitamin C and E are antioxidants with little direct impact on osteoporosis. So calcium with vitamin D is the most appropriate supplement.