Which enzyme is a liver enzyme commonly evaluated in liver function testing?

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Multiple Choice

Which enzyme is a liver enzyme commonly evaluated in liver function testing?

Explanation:
Alanine aminotransferase is a liver-specific enzyme that clinicians routinely include in liver function tests to detect hepatocellular injury. When liver cells are damaged, ALT leaks into the bloodstream, so elevated ALT levels indicate liver-origin pathology such as hepatitis, fatty liver disease, or drug-induced liver injury. The other options relate to kidney function—GFR estimates how well the kidneys filter blood, while BUN and creatinine measure waste products cleared by the kidneys. They are not liver enzymes and wouldn’t specifically indicate liver injury. Therefore, ALT is the enzyme most commonly evaluated in liver function testing.

Alanine aminotransferase is a liver-specific enzyme that clinicians routinely include in liver function tests to detect hepatocellular injury. When liver cells are damaged, ALT leaks into the bloodstream, so elevated ALT levels indicate liver-origin pathology such as hepatitis, fatty liver disease, or drug-induced liver injury. The other options relate to kidney function—GFR estimates how well the kidneys filter blood, while BUN and creatinine measure waste products cleared by the kidneys. They are not liver enzymes and wouldn’t specifically indicate liver injury. Therefore, ALT is the enzyme most commonly evaluated in liver function testing.

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