Which medication is NOT a first-line anti-tuberculosis drug?

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Multiple Choice

Which medication is NOT a first-line anti-tuberculosis drug?

Explanation:
First-line TB drugs are the ones used in the standard initial four-drug regimen for drug-susceptible TB. The core group includes isoniazid, rifampin, pyrazinamide, and ethambutol. Streptomycin, while historically used for TB, is no longer a first-line option in most modern regimens because it is an injectable with notable toxicity (ototoxicity and nephrotoxicity) and there are effective oral alternatives. It is now generally reserved as a second-line injectable agent for resistant TB or specific situations where first-line drugs cannot be used. So streptomycin is not a first-line anti-tuberculosis drug.

First-line TB drugs are the ones used in the standard initial four-drug regimen for drug-susceptible TB. The core group includes isoniazid, rifampin, pyrazinamide, and ethambutol. Streptomycin, while historically used for TB, is no longer a first-line option in most modern regimens because it is an injectable with notable toxicity (ototoxicity and nephrotoxicity) and there are effective oral alternatives. It is now generally reserved as a second-line injectable agent for resistant TB or specific situations where first-line drugs cannot be used. So streptomycin is not a first-line anti-tuberculosis drug.

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